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Incapsula incident ID: 328000730145108444-592231661782438482

GI dysfunction, a common comorbidity in PD, further contributes to fluctuations in levodopa absorption and plasma concentrations, thereby triggering or exacerbating the on-off phenomenon [86, 87]

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Pharmacokinetics and bioavailability of oral acetylcysteine in healthy volunteers

Based on this evidence, the principle of senolytic approaches is to target Senecent Cell Anti-Apoptotic Pathways (SCAPs) by inhibiting or activating proteins which regulate this apoptosis resistance 8,9